Elevated Kappa Light Chain Ratio

An abnormal light chain ratio has been defined as a kappa to lambda chain ratio of less than 0 26 or more than 1 65.

Elevated kappa light chain ratio.

In the context of mgus or myeloma significantly increased free light chain production and a markedly abnormal kappa lambda ratio indicate an increased risk of disease progression. Kappa light chain concentration range. Increased lambda free light chains and a decreased kappa lambda ratio may be seen with plasma cell disorders that produce excess monoclonal lambda light chains. Normal values for kappa lambda and flc ratio.

I also have these lab results kappa free light chain serum 47 8 mg l 3 3 19 4 mg l lambda free light chain serum 13 5 mg l 5 7 26 3 mg l kappa lambda ratio serum 3 54 i just want to know how ba read more. 5 7 26 3 mg ml. Epub 2015 jun 3. Authors aneta niewmierzycka.

Lambda light chain concentration range. There are two types of light chains. In a healthy individual the total kappa to lambda ratio is roughly 2 1 in serum measuring intact whole antibodies or 1 1 5 if measuring free light chains with a highly divergent ratio indicative of neoplasm. It is normal for there to be small fluctuations in the uninvolved light chain concentration over time which have no clinical significance at all.

The ratio or proportion between the kappa and lambda light chains indicates an excess production of one chain over the other and therefore can be used as an indication of disease progression or remission said dr. Prevalence and clinical significance of abnormal serum kappa lambda light chain ratio in patients with chronic kidney disease pol arch med wewn. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells. Abnormal free light chain production has also been reported to be prognostic of a worse outcome in multiple myeloma and chronic lymphocytic leukaemia.

This balance of kappa and lambda together is called the kappa lambda ratio which can also indicate a change in levels of disease. These unlinked chains are known as free light chains. Lambda and kappa light chains. She told me not to worry and we ll check again in 3 months.

You have a minimal degree of change this may be wi. The exact normal ratio of kappa to lambda according to a novel polyclonal free light chain assay ranges from 0 26 to 1 65.